HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985637Generated: November 2, 2026
Dichloromethane → [4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone
https://huagongshe.com/reaction/1985637
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Reactant | 1-[2-(Trifluoromethyl)benzoyl]piperazine | HCID 16733784 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone | HCID 66849536 | 52% |
Reaction Steps
The mixture of 3-amino-6-chloropyridazine (0.6487 g, 5 mmol) and piperazin-1-yl-(2-trifluoromethylphenyl)methanone (1.936 g, 7.5 mmol) in NMP (30 mL) was heated at 150° C. for 24 hours. To the reaction mixture was added 10 mL of 1 N NaOH and 100 mL of dichloromethane, and the aqueous layer was separated and extracted twice by 100 mL dichloromethane. The combined organic phase was dried over Na2SO4, evaporated to dryness. The crude compound was purified by flash chromatography to give yellow solid. Yield 52%, 1.37 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07547698B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-a0d14503d08e4996b52aa41c7240a2d0 |
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| Source note | uspto-grants-2009_06 |
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