Pentylamine → HCID 11598315, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations only as required to use n-pentylamine in place of isoamylamine to react with 6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]imidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester, the title compound was obtained as a white solid in 56% yield (0.062 g). m.p. 179-180° C. 1H NMR (300 MHz, CDCl3) δ 8.14 (s, 1H), 7.75-7.5 (m, 4H), 7.38-7.27 (s, 2H), 6.89 (d, J=9.6 Hz, 1H), 4.07-3.8 (m, 2H), 3.7-3.51 (m, 2H), 3.5-3.28 (m, 6H), 1.68-1.52 (m, 2H), 1.45-1.28 (m, 4H), 0.89 (t, J=2.1 Hz, 3H). 13C NMR (75 MHz, CDCl3) δ 167.5, 162.3, 154.8, 138.2, 134.3, 134.2, 132.4, 129.5, 127.1, 126.8, 126.8, 126.2, 125.4, 121.8, 118.2, 111.9, 46.2, 41.2, 39.1, 29.4, 29.1, 22.4, 13.9. MS (ES+) m/z 489.2 (M+1).

Provenance & Evidence