Reaction Steps
Following the procedure as described in Example 3, making variations only as required to use n-hexanoic acid in place of butyric acid to react with [4-(3,4-diaminophenyl)piperazin-1-yl](2-trifluoromethylphenyl)methanone, the title compound was obtained as a yellow syrup in 57% yield (0.347 g). 1H NMR (300 MHz, CDCl3) δ 8.8 (br., s, 1H), 7.70 (d, J=7.7 Hz, 1H), 7.64-7.45 (m, 2H), 7.36 (d, J=8.7 Hz, 1H), 6.99 (s, 1H), 6.87 (dd, J=1.9, 8.7 Hz, 1H), 4.00-3.91 (m, 2H), 3.33 (t, J=4.8 Hz, 2H), 3.15 (t, J=5.1 Hz, 2H), 3.05-2.95 (m, 2H), 2.82 (t, J=7.7 Hz, 2H), 1.85-1.70 (m, 2H), 1.33-1.16 (m, 4H), 0.79 (t, J=7.0 Hz, 3H). 13C NMR (75 MHz, CDCl3) δ 167.5, 155.3, 147.4, 138.4, 134.5, 134.0, 132.3, 129.3, 127.2, 127.1, 126.8, 126.8, 126.7, 126.6, 125.4, 121.8, 115.4, 115.3, 114.9, 102.3, 51.3, 51.1, 47.3, 41.9, 31.4, 29.1, 27.9, 22.3, 13.9. MS (ES+) m/z 445.2 (M+1).
