HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985664Generated: October 31, 2026
Sodium Hydroxide → 2-Amino-3-cyano-4-chloro-6-(morpholin-4-yl)quinoline
https://huagongshe.com/reaction/1985664
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178510459 | HCID 178510459 | — |
| Product | 2-Amino-3-cyano-4-chloro-6-(morpholin-4-yl)quinoline | HCID 66850453 | — |
Reaction Steps
The mixture of 1.7 g of 2-amino-3-cyano-4-hydroxy-6-(morpholin-4-yl)quinoline and 3.4 mL of phosphoryl chloride is stirred at 120° C. for 4 hours. The cooled reaction mixture is poured onto 30 g of ice, the pH of the mixture is adjusted to 8 with 10% NaOH solution, and the precipitated material is filtered off. After drying 1.5 g of the title compound is obtained, m.p.: 206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07547696B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-ed71a35a850040c7a1b9499941c9c29c |
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| Source note | uspto-grants-2009_06 |
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