反应详情

A suspension of 3.5 g of 2-amino-3-cyano-4-benzylamino-6-nitroquinoline in 50 mL of dry pyridine was refluxed with 5.6 g of 4-methoxybenzoyl chloride for 3.5 hours. The solvent was evaporated in reduced pressure and the residue was suspended in 30 mL of a saturated solution of Na2CO3 in water. The suspension was extracted with 3×25 mL of CH2Cl2. The combined organic extract was evaporated to dryness, the residue was dissolved in diethyl ether and the solution was kept in a refrigerator for a night. The precipitate was filtered off, washed with diethyl ether to give 6.25 g of the title compound, m.p.: 145-148° C. LC-MS: MH+ 588; Ret. time: 7.00 min.

1. customThe solvent was evaporated in reduced pressure
2. extractionThe suspension was extracted with 3×25 mL of CH2Cl2
3. extractionThe combined organic extract
4. customwas evaporated to dryness
5. dissolutionthe residue was dissolved in diethyl ether
6. waitthe solution was kept in a refrigerator for a night
7. filtrationThe precipitate was filtered off
8. washwashed with diethyl ether