HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(4-Bromophenyl)-4,7-dichloroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 135442630 | HCID 135442630 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Bromophenyl)-4,7-dichloroquinazoline | HCID 51358609 | — |
Reaction Steps
2-(4-Bromo-phenyl)-7-chloro-3H-quinazolin-4-one (38.7 mmol) is added to 50 ml thionylchloride and is heated at 40°. The mixture is treated with 6 ml dimethylformamide (DMF). After cooling to rt the mixture is stirred for 3 hrs. Customary working up gives 2-(4-bromo-phenyl)-4,7-dichloroquinazoline as a solid; m.p. 189-190°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547702B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-791ba3de01a64376a50bdc332059829b |
| Source note | uspto-grants-2009_06 |