Potassium Carbonate → HCID 68863255, compound

Participants

Reaction Steps

1,2 Equivalents of K2CO3, 1,2 equivalents of 4-chlorophenylboronic acid and 10 mol % of Pd((PPh3)4 are added to a solution of N′-[2-(4-bromo-phenyl)-7-chloro-quinazolin4-yl]-N,N-diethyl-propane-1,3-diamine (16,5 mmol) in 80 ml of DMF and it is heated at 80° until conversion is complete. After filtering off the catalyst and customary working up for solution reactions, N′-[7-chloro-2-(4′-chloro-biphenyl-4-yl)-quinazolin-4-yl]-N,N-diethyl-propane-1,3-diamine is obtained.

Provenance & Evidence