Aluminium lithium hydride → HCID 11997228, compound

Participants

Reaction Steps

A mixture of 0.100 g (5R,8aR)-5-methyl-3,5,6,8,8a,9-hexahydro-1H-2-oxa-4,4b,7-triaza-cyclopenta[b]fluorene-7-carboxylic acid tert-butyl ester and 0.040 g lithium aluminum hydride in 3 ml tetrahydrofuran was heated to reflux for 2 h. The reaction mixture was cooled to room temperature and partitioned between water and ethyl acetate. The organic phase was washed with brine evaporated and purified by chromatography on silica gel with dichloromethane:methanol:ammonia=90:10:1. to yield 0.053 g of the title compound as slightly yellow gum (MS: 246.4 (M+H+))

Provenance & Evidence