HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1985758Generated: October 26, 2026
2-Bromopropanedial → 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde
https://huagongshe.com/reaction/1985758
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromopropanedial | HCID 74945 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | (4-Methyl-pyridin-2-yl)-thiourea | HCID 2760059 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde | HCID 22019084 | 80% |
Reaction Steps
A mixture of (4-methylpyridin-2-yl)-thiourea (334 mg, 2 mmol), 2-bromomalonaldehyde (302 mg, 2 mmol) and sodium acetate (250 mg, 3.0 mmol) in acetic acid (5 mL) was stirred at 100° C. for 3 h. The mixture was cooled to RT and diluted with water and the precipitate formed was collected, washed with water and dried to afford 2-(4-methylpyridin-2-ylamino)-thiazole-5-carbaldehyde (350 mg, 80%). MS m/z 220 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07547711B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-baff89fb0ab445b085510ebfc367b3f6 |
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| Source note | uspto-grants-2009_06 |
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