Benzoyl isothiocyanate → Ethyl 6-(3-benzoyl-thioureido)-nicotinate

Participants

Reaction Steps

A solution of ethyl 6-amino-nicotinate (830 mg, 5 mmol) and benzoyl isothiocyanate (830 mg, 5.1 mmol) in acetone was refluxed for 2 h. The mixture was concentrated to thin slurry and methanol was added. The solid was filtered, washed with methanol and dried to afford ethyl 6-(3-benzoyl-thioureido)-nicotinate (1.35 g, 82%). 1H NMR (CDCl3) δ 13.34 (s, 1H), 9.04 (m, 3H), 8.38 (s, 1H), 7.93 (m, 2H), 7.66 (m, 3H), 4.42 (q, 2H, J=7.6 Hz), 1.41 (t, 3H, J=7.6 Hz).

Provenance & Evidence