HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-amino-N-cyclopropyl-2,4-difluorobenzamide → 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-amino-N-cyclopropyl-2,4-difluorobenzamide | HCID 21966507 | — |
| Reactant | 6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid | HCID 22019054 | — |
| Product | 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid | HCID 23544562 | 95% |
Reaction Steps
6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid (see Example 19) was treated with 5-amino-2,4-difluoro-N-cyclopropylbenzamide in manner similar to the preparation of Example 6 to afford the title compound in 95% yield. LC/MS; (M+H)+=446
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547711B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-be38a8ea2f544ad99a59a26cc4085c5b |
| Source note | uspto-grants-2009_06 |