Methanol → HCID 68863165, compound

Participants

Reaction Steps

(R)-tert-Butoxycarbonylamino-3-(pyrazin-2-ylmethanesulfonyl)propionic acid (1.42 g, 4.53 mmol) was dissolved in mixture of MeOH (10 mL) and toluene (33 mL) and Me3SiCHN2 (2.0 M solution in hexanes, 3.06 ml) was added dropwise over 10 min. After stirring the reaction mixture overnight, the solvent was removed and the resulting residure was purified by flash chromatography with EtOAc/hexanes as eluent to afford methyl 2(R)-tert-butoxycarbonylamino-3-(pyrazin-2-ylmethanesulfonyl)propionate (0.755 g).

Provenance & Evidence