Methanol → HCID 66894422, compound

HRID 1985810Notes

Reaction equation

HRID 1985810 reaction equation
[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:13])[C:3]([OH:5])=[O:4].[CH3:14]O>>[ClH:13].[CH3:14][O:4][C:3](=[O:5])[C@@H:2]([NH2:1])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:13]

Participants

3

Reactant 2

HCID 887MethanolHCID 27614912-Chloro-L-phenylalanine

Product 1

HCID 66894422HCID 66894422, compound

Procedure

2(S)-Amino-3-(2-chlorophenyl)propionic acid (1 g, commercially available) was dissolved in methanol (10 mL) and HCl gas was bubbled through the solution for 5 min. The reaction mixture was stirred at room temperature for 3 h and the solvent was evaporated using the rotavap to get 2(S)-amino-3-(2-chlorophenyl)propionic acid methyl ester hydrochloride (1.2 g).

Workup

  1. customHCl gas was bubbled through the solution for 5 min
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-b21c25fc386f40ea977dd0f731e0f883
Source dataset
uspto-grants-2009_06
Patent number
US07547701B2

Reaction notes

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