HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4,5-Dichloro-1,2-phenylenediamine | HCID 79297 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One | HCID 9899148 | 101.1% |
Reaction Steps
4,5-Dichloro-1,2-phenylenediamine (10 g) was dissolved in tetrahydrofuran (35 mL), and to the mixture was added a suspension of carbonyldiimidazole (9.6 g) in tetrahydrofuran (15 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 hour, and to the reaction mixture was added water under ice-cooling. The insoluble material was collected by filtration and dried to give the title compound (11.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547680B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-a20f4ca89b17436a9cd7d8df2b03fccb |
| Source note | uspto-grants-2009_06 |