4-(Benzyloxy)-3-[4-(benzyloxy)butoxy]benzonitrile → HCID 23143889, compound

Participants

Reaction Steps

4-Benzyloxy-3-(4-benzyloxybutoxy)benzonitrile (4.0 g) was dissolved in a mixed solvent of trifluoroacetic acid (9 mL), dimethylsulfide (0.5 mL) and water (5 mL), and the mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5) to give the title compound (1.0 g).

Provenance & Evidence