Ethanol → HCID 23143862, compound

Participants

Reaction Conditions

Reaction Steps

Lithium aluminium hydride (2.6 g) was suspended in tetrahydrofuran (30 mL), and to the mixture was added dropwise a solution of 4-benzyloxy-3-(4-benzyloxybutoxy)benzonitrile (5.9 g) in tetrahydrofuran (30 mL) under ice-cooling. The mixture was stirred at 60° C. for 2 hours. After the mixture was cooled in an ice bath, ethanol and water were successively added dropwise to the reaction mixture. To the reaction mixture was added anhydrous sodium sulfate, and the insoluble material was removed by filtration through celite. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by column chromatography on aminopropylated silica gel (eluent: ethyl acetate/hexane=1/5) to give the title compound (2.5 g).

Provenance & Evidence