Hydrochloric Acid → HCID 57720190, compound

Participants

Reaction Steps

2-(3-Ethoxycarbonylmethyloxy-4-phenylbenzylamino)-1-(β-D-ribofuranosyl)-1H-benzimidazole (53 mg) was dissolved in methanol (5 mL). To the mixture was added sodium tetrahydroborate (8 mg), and the mixture was stirred at room temperature for 1 hours. To the reaction mixture was added 1 mol/L hydrochloric acid (0.5 mL), and the solvent was removed under reduced pressure. The obtained residue was purified by preparative reverse phase column chromatography (Shiseido CAPSELL PAC C18UG80, 5 μm, 20×50 mm, flow rate 30 mL/minutes linear gradient, water/methanol=70/30-10/90) to give the title compound (21 mg).

Provenance & Evidence