Hydrochloric Acid → HCID 69047344, compound

Participants

Reaction Steps

4-(Aminomethyl)benzoic acid (726 mg, 4.8 mmol) and triethylamine (0.67 ml, 4.8 mmol) were dissolved in a mixed solution of 2N sodium hydroxide solution (2.4 ml, 4.8 mmol), dioxane (4.8 ml) and water (12 ml). A suspension of N-[5-(chlorosulfonyl)-1-naphthalenyl]acetamide (1.135 g, 4 mmol) in dioxane (4 ml) and methanol (12 ml) was added to the mixture under ice cooling and stirring, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into diluted hydrochloric acid, and the precipitated solid was washed with water and dried under reduced pressure to give the title compound as a light brown crystal (1,361 g, 85.4%).

Provenance & Evidence