Trimethylsilyldiazomethane → HCID 68427113, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of amino(6,6-difluorobicyclo[3.1.0]hex-3-yl)acetic acid (1.0 g, 5.23 mmol) in CH2Cl2:MeOH (4:1) was added dropwise TMSCHN2 (10.5 mL) over 10 min at 0° C. until a neon yellow color persisted. The reaction mixture was allowed to warm to 25° C. over 19 h. The solvent was removed in vacuo to obtain methyl amino(6,6-difluorobicyclo[3.1.0]hex-3-yl)acetate as a light yellow oil (0.9 g, 84.11%). Mass Spectrum (−ESI): 206 (M+H)+.

Provenance & Evidence