Ethylamine → 3,5-Dichloro-N-ethyl-2-hydroxybenzamide

HRID 1985988Notes

Reaction equation

HRID 1985988 reaction equation
[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([OH:7])=O.[CH2:13]([NH2:15])[CH3:14]>>[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([NH:15][CH2:13][CH3:14])=[O:7]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 94453,5-Dichlorosalicylic acid

Product 1

HCID 539124643,5-Dichloro-N-ethyl-2-hydroxybenzamide

Procedure

The title compound was prepared from 3,5-dichloro-2-hydroxybenzoic acid and ethylamine, using a similar method to that of preparation 52, to afford the title compound as a pale yellow solid. 1HNMR (400 MHz, CDCl3) δ: 1.28 (3H, t), 3.47-3.54 (2H, m), 6.29-6.36 (1H, bs), 7.27 (1H, d), 7.48 (1H, d); LRMS ESI m/z 232 [M−H]−

Workup

  1. customof preparation 52

Sources & evidence

ORD record
ord-1de847e7e3a64212b066711a4261700c
Source dataset
uspto-grants-2009_06
Patent number
US07547731B2

Reaction notes

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