HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt → 2-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223007 | — |
| Reactant | 4-(4-Amino-2-fluorophenoxy)picolinamide | HCID 23153205 | — |
| Product | 2-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide | HCID 57721364 | 37% |
Reaction Steps
4-(4-Amino-2-fluorophenoxy)picolinamide (0.12 g, 0.50 mmol) was converted to the desired compound (0.088 g, 37%) in a manner similar to the preparation of 2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-nicotinamide (Example 2). HRMS(ESI+), 480.1283 (M+H)+ calc, 480.1281 (M+H)+ found.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547782B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2b5c3457401646ffba13bbd1a766cb45 |
| Source note | uspto-grants-2009_06 |