反应详情

4-(4-Amino-2-fluorophenoxy)picolinamide (0.12 g, 0.50 mmol, Compound C of Example 3) was converted to the desired compound (0.090 g, 47%) in a manner similar to the preparation of 2-(4-(2-carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-nicotinamide (Step D of Example 3), except that 2-chloro-N-(4-chlorophenyl)nicotinamide (Maybridge, 0.11 g, 0.40 mmol) was used instead of 2-chloro-N-(2,4-difluorophenyl)nicotinamide. HRMS(ESI+), 478.1082 (M+H)+ calc, 478.1059 (M+H)+ found.