2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt → 2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(4-chlorophenyl)-nicotinamide, hydrochloride salt

Participants

Reaction Steps

2-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(4-chlorophenyl)nicotinamide (0.088 g, 0.18 mmol) was converted to the title compound (0.022 g, 25%) in a manner similar to the preparation of 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide (Step E of Example 3). 1H NMR (DMSO-d6) δ 10.65 (s, 1H), 10.40 (s, 1H), 8.36 (dd, 1H, J=4.9, 1.6 Hz), 8.25-8.28 (m, 1H), 8.11 (dd, 1H, J=13.6, 2.4 Hz), 7.71-7.92 (m, 5H), 7.29-7.45 (m, 4H), 6.98 (dd, 1H, J=7.7, 4.9 Hz), 6.65 (dd, 1H, J=7.3, 2.5 Hz), 6.13 (d, 1H, J=2.4 Hz);

Provenance & Evidence