HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt → 4-(4-(3-(2,4-Difluorophenylcarbamoyl)pyridin-4-ylamino)-2-fluorophenoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223005 | — |
| Reactant | 2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223105 | — |
| Product | 4-(4-(3-(2,4-Difluorophenylcarbamoyl)pyridin-4-ylamino)-2-fluorophenoxy)picolinamide | HCID 57721361 | 12% |
Reaction Steps
4-(4-Amino-2-fluorophenoxy)picolinamide (0.12 g, 0.50 mmol, Compound C of Example 3) was converted to the desired compound (0.030 g, 12%) in a manner similar to the preparation of 4-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-di-fluorophenyl)nicotinamide (Step D of Example 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547782B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-10e5d0ec67b04d2796560c7e32b78add |
| Source note | uspto-grants-2009_06 |