2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt → 2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-benzylnicotinamide, dihydrochloride salt

Participants

Reaction Steps

4-(4-(3-(Benzylcarbamoyl)pyridin-2-ylamino)-2-fluorophenoxy)picolinamide (0.068 g, 0.15 mmol) was converted to the title compound (0.051 g, 69%) in a manner similar to the preparation of 2-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide (Step E of Example 3). 1H NMR (DMSO-d6) δ 11.17 (s, 1H), 9.44 (t, 1H, J=5.7 Hz), 8.10-8.35 (m, 3H), 7.91 (d, 1H, J=7.2 Hz), 7.82 (br s, 2H), 7.15-7.42 (m, 7H), 6.90-6.94 (m, 1H), 6.65 (dd, 1H, J=7.2, 2.5 Hz), 6.12 (d, 1H, J=2.5 Hz), 4.45 (d, 2H, J=5.8 Hz); HRMS(ESI+), 430.1679 (M+H)+ calc, 430.1683 (M+H)+ found.

Provenance & Evidence