2-Fluoro-N-(4-fluoro-2-methylphenyl)nicotinamide → 2-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(4-fluoro-2-methylphenyl)nicotinamide, dihydrochloride salt

Participants

Reaction Steps

2-Fluoro-N-(4-fluoro-2-methylphenyl)nicotinamide (0.050 g, 0.20 mmol) was converted to the title compound (0.043 g, 42%) in a manner similar to the preparation of 2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-o-tolylnicotinamide (Step B of Example 8). 1H NMR (DMSO-d6) δ 12.85 (s, 1H), 10.87 (s, 1H), 10.28 (s, 1H), 8.10-8.40 (m, 4H), 6.96-7.60 (m, 7H), 6.72 (d, 1H, J=6.5 Hz), 6.45-6.53 (m, 1H), 2.20 (s, 3H); HRMS(ESI+), 472.1580 (M+H)+ calc, 472.1590 (M+H)+ found.

Provenance & Evidence