4-Fluorobenzylamine → 2-Fluoro-N-(4-fluorobenzyl)nicotinamide

HRID 1986082Notes

Reaction equation

HRID 1986082 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[F:10][C:11]1[N:26]=[CH:25][CH:24]=[CH:23][C:12]=1[C:13](NC1C=CC=CC=1C)=[O:14]>>[F:10][C:11]1[N:26]=[CH:25][CH:24]=[CH:23][C:12]=1[C:13]([NH:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=1)=[O:14]

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 577213712-Fluoro-N-o-tolylnicotinamide

Product 1

HCID 577213352-Fluoro-N-(4-fluorobenzyl)nicotinamideYield 100%

Procedure

4-Fluorobenzylamine (Aldrich, 0.18 mL, 1.6 mmol) was converted to the desired compound (0.099 g, 100%) in a manner similar to the preparation of 2-fluoro-N-o-tolylnicotinamide (Step A of Example 8). MS(ESI+) m/z 249 (M+H)+.

Sources & evidence

ORD record
ord-572bdc669b674a24a909f939bac086b8
Source dataset
uspto-grants-2009_06
Patent number
US07547782B2

Reaction notes

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