2-Fluoro-N-(4-fluorobenzyl)nicotinamide → 2-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(4-fluorobenzyl)nicotinamide, dihydrochloride salt

Participants

Reaction Steps

2-Fluoro-N-(4-fluorobenzyl)nicotinamide (0.050 g, 0.20 mmol) was converted to the title compound (0.035 g, 35%) in a manner similar to the preparation of 2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-o-tolylnicotinamide (Step B of Example 8). 1H NMR (DMSO-d6) δ 12.63 (s, 1H), 11.17 (s, 1H), 9.44 (t, 1H, J=5.8 Hz), 8.10-8.40 (m, 4H), 7.50-7.60 (m, 1H), 7.30-7.45 (m, 4H), 7.08-7.10 (m, 2H), 6.90-6.95 (m, 1H), 6.66 (d, 1H, J=6.3 Hz), 6.43-6.46 (m, 1H), 4.44 (d, 2H, J=5.7 Hz); HRMS(ESI+), 472.1585 (M+H)+ calc, 472.1587 (M+H)+ found.

Provenance & Evidence