HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Morpholin-4-yl)-1-phenylethan-1-amine → 2-Fluoro-N-(2-morpholino-1-phenylethyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Morpholin-4-yl)-1-phenylethan-1-amine | HCID 2814462 | — |
| Reactant | 2-Fluoro-N-o-tolylnicotinamide | HCID 57721371 | — |
| Product | 2-Fluoro-N-(2-morpholino-1-phenylethyl)nicotinamide | HCID 57721330 | 87% |
Reaction Steps
2-Morpholin-4-yl-1-phenylethylamine (Array Biopharma, Inc., 0.33 g, 1.6 mmol) was converted to the desired compound (0.12 g, 87%) in a manner similar to the preparation of 2-fluoro-N-o-tolylnicotinamide (Step A of Example 8). HRMS(ESI+), 330.1618 (M+H)+ calc, 330.1620 (M+H)+ found.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547782B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-b7c0b56243bf4b6882aacf455622be68 |
| Source note | uspto-grants-2009_06 |