HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorobenzeneboronic acid → (1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4,4-difluoropiperidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| Reactant | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Product | (1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(4,4-difluoropiperidin-1-yl)methanone | HCID 16739525 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 3,4-dichlorophenylboronic acid. The title compound was obtained in 81% yield as yellow foam. MS (m/e): 550.2 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d4bb8722977941e6945f970d1a5873ce |
| Source note | uspto-grants-2010_06 |