HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131727491, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester | HCID 80008 | — |
| Reactant | 4-(4-(1h-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-n-(2,4-difluorophenyl)nicotinamide, hydrochloride salt | HCID 16223005 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 131727491 | HCID 131727491 | 93% |
Reaction Steps
To a mixture of ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (Alpha Aesar, 2.08 g, 8.93 mmol) and 4-(4-amino-2-fluorophenoxy)picolinamide (2.0 g, 8.09 mmol, Compound C of Example 3) in NMP (10 mL) was added a solution of 4 N HCl in 1,4-dioxane (4 mL, 16 mmol). After stirring overnight, the reaction mixture was diluted with water (200 mL) and the resulting solid was filtered and dried in vacuo to give the desired product (3.6 g, 93%) as a white solid. MS(ESI+) m/z 444 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547782B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-9c1e8c33c621412fb9abf896854f26d5 |
| Source note | uspto-grants-2009_06 |