HCID 57721327, compound → HCID 57721356, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-(4-(2-carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-2-(methylthio)pyrimidine-5-carboxylate (260 mg, 0.58 mmol) in ethanol (5 mL) was added Raney nickel in water (Raney®2400, approx. 3 g). The mixture was heated to 70° C. and was allowed to stir overnight. The mixture was filtered through Celite® and the filtrate was concentrated in vacuo to give the desired product (91 mg, 39%) as a solid. MS(ESI+) m/z 398 (M+H)+.

Provenance & Evidence