HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-(2,5-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-(4-(2,5-dimethylbenzyloxy)phenyl)4-oxobutyrate | HCID 21964479 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-(2,5-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid | HCID 12132308 | — |
Reaction Steps
To a solution of Ethyl 4-(4-(2,5-dimethylbenzyloxy)phenyl)-4-oxobutyrate (Step B, 2.62 g, 7.7 mmol) in abs ethanol (30 ml) was added 1N NaOH (10 ml) at room temperature. The reaction mixture was stirred for 3 hours and then acidified with 1M HCl. The occurring white precipitate was filtered, washed with water and dried under vacuum to provide the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547802B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-389109c2aaa445e9bfaec0abf8ba8ee8 |
| Source note | uspto-grants-2009_06 |