Potassium Hydroxide → 4-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

HRID 1986139Notes

Reaction equation

HRID 1986139 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[K+:25]>C(O)C>[K+:25].[CH3:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([O-:17])=[O:16])[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 9926783HCID 9926783, compound

Product 1

HCID 208123284-(3-(2,6-Dimethylbenzyloxy)phenyl)4-oxobutyric acid Potassium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D, 6.0 g, 19.4 mmol) was dissolved in abs ethanol (20 ml) by warming gently followed by addition of KOH (1.21 g) at 0° C. temperature. The reaction mixture was stirred for one hour, concentrated in vaccuo and lyophilized to give the title compound as white solid.

Workup

  1. temperatureby warming gently
  2. concentrationconcentrated in vaccuo

Sources & evidence

ORD record
ord-4a1668b3772e4576a78a09eeb32248e2
Source dataset
uspto-grants-2009_06
Patent number
US07547802B2

Reaction notes

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