HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Rasagiline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Rasagiline mesylate | HCID 3052775 | — |
| Solvent | Water | HCID 962 | — |
| Product | Rasagiline | HCID 3052776 | — |
Reaction Steps
120 g of rasagiline mesylate (R(+)-N-propargyl-1-aminoindan mesylate) were dissolved in 700 ml of deionized water. 400 ml of toluene were added and the mixture was basified with 25% NaOH solution to a pH of about 14. After stirring, two phases separated. The lower water phase was extracted with 200 ml of toluene. The phases were allowed to separate and the aqueous phase was discarded.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547806B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-6110342d560d4da6b9ef34a9ff8a38b7 |
| Source note | uspto-grants-2009_06 |