Hydrazine → 3-(4-Benzhydryl-2,6-cis-dimethyl-piperazin-1-yl)-propylamine

Participants

Reaction Conditions

Reaction Steps

Hydrazine (1.10 g, 34.2 mmol) is added to a stirred solution of 2-[3-(4-benzhydryl-2,6-cis-dimethylpiperazin-1-yl)-propyl]-isoindole-1,3-dione (1.98 g, 4.28 mmol) in ethanol (70 mL). The mixture is heated at 70° C. for 12 hours to form a suspension. At room temperature the mixture is filtered and the filtrate is concentrated to give 3-(4-benzhydryl-2,6-cis-dimethyl-piperazin-1-yl)-propylamine (1.02 g, 71% yield) as an oil.

Provenance & Evidence