1-(3-Aminopropyl)-4-methylpiperazine → HCID 68857906, compound

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Reaction Steps

A mixture of [2-(2-chloro-5-methylpyrimidin-4-yl)-benzo[b]thiophen-6-yl]-carbamic acid tert-butyl ester (0.32 g, 0.85 mmol) and 1-(3-aminopropyl)-4-methylpiperazine (0.41 g, 2.6 mmol) in 1,4-dioxane (15 mL) is refluxed for 48 hours. Solvent is removed and the residue is chromatographed on silica gel, eluting with 2.0 M NH3/MeOH in dichloromethane 0-10%, to obtain the title compound as a yellow solid (0.33 g, 78% yield). ES+(m/z) 497 [M+H].

Provenance & Evidence