Cyclopropylamine → HCID 86625353, compound

Participants

Reaction Steps

To a stirred suspension of 2-(2,5-dichloropyrimidin-4-yl)-7-methoxybenzo[b]thiophene-4-carboxylic acid (2.50 g, 3.07 mmol) is added diisopropylethylamine (1.12 mL, 6.44 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (617 mg, 3.22 mmol) and 1-hydroxybenzotriazole (435 mg, 3.22 mmol) at room temperature under nitrogen atmosphere. The mixture is treated with cyclopropylamine (184 mg, 3.22 mmol) and stirred at room temperature for 1 day. The mixture is diluted with dichloromethane (60 mL) and washed with water (3×30 mL). The organic phase suspension is filtered off to give a yellow solid which is washed with dichloromethane and water to give the title compound as a yellow solid (880 mg, 72% yield).

Provenance & Evidence