1-Tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate → 4-(3-Aminopropyl)-4-ethylpiperidine-1-carboxylic acid tert-butyl ester

HRID 1986213Notes

Reaction equation

HRID 1986213 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][CH2:17][NH2:18])([CH3:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:19]OC(C1(CC)CCN(C(OC(C)(C)C)=O)CC1)=O>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][CH2:17][NH2:18])([CH2:14][CH3:19])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 463183891-Tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylateHCID 68857055Tert-butyl 4-(3-aminopropyl)-4-methylpiperidine-1-carboxylate

Product 1

HCID 688567424-(3-Aminopropyl)-4-ethylpiperidine-1-carboxylic acid tert-butyl ester

Procedure

Using the method of 4-(3-aminopropyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester, the title compound is synthesized from 4-ethylpiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester and isolated as a clear oil.

Workup

  1. customisolated as a clear oil

Sources & evidence

ORD record
ord-7d228e8064d946709b323f3d15e9d5a9
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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