Hydrochloric Acid → HCID 68857385, compound

Participants

Reaction Steps

Aqueous LiOH solution (2.5 N, 2.0 mL) is added to a stirred solution of 4-{3-[4-(4-methoxycarbonyl-benzo[b]thiophen-2-yl)-pyrimidin-2-ylamino]-propyl}-piperazine-1-carboxylic acid tert-butyl ester (700 mg, 1.49 mmol) in THF (7 mL)/MeOH (4 mL), the resultant mixture is stirred at 40° C. for 4 hours. At 40° C., 5 N HCl (2.1 mL) is added in one shot to the reaction mixture. Within 2 minutes the mixture becomes a suspension. After filtration and drying, the title compound is obtained as a yellow solid (950 mg, 99% yield).

Provenance & Evidence