2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide → 2-{5-Chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride

HRID 1986228Notes

Reaction equation

HRID 1986228 reaction equation
[ClH:1].Cl.C1(NC(C2C3C=C(C4C(C)=CN=C(NCCCN5CCN(C)CC5)N=4)SC=3C=CC=2)=O)CC1.[CH:36]1([NH:39][C:40]([C:42]2[C:50]3[CH:49]=[C:48]([C:51]4[C:56]([Cl:57])=[CH:55][N:54]=[C:53]([NH:58][CH2:59][CH2:60][CH2:61][N:62]5[CH2:67][CH2:66][N:65]([CH3:68])[CH2:64][CH2:63]5)[N:52]=4)[S:47][C:46]=3[CH:45]=[CH:44][CH:43]=2)=[O:41])[CH2:38][CH2:37]1>>[ClH:57].[ClH:1].[CH:36]1([NH:39][C:40]([C:42]2[C:50]3[CH:49]=[C:48]([C:51]4[C:56]([Cl:57])=[CH:55][N:54]=[C:53]([NH:58][CH2:59][CH2:60][CH2:61][N:62]5[CH2:63][CH2:64][N:65]([CH3:68])[CH2:66][CH2:67]5)[N:52]=4)[S:47][C:46]=3[CH:45]=[CH:44][CH:43]=2)=[O:41])[CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 167207622-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamideHCID 688548052-{5-Methyl-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride

Product 1

HCID 689058162-{5-Chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride

Procedure

Using the method of 2-{5-methyl-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride, the title compound is synthesized from 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and obtained as a solid. ES+(m/z) 485 (35Cl) and 487 (37Cl) [M+H].

Workup

  1. customobtained as a solid

Sources & evidence

ORD record
ord-0eca2a2f199d449f9694aced5c24a667
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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