HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride → 1-(3-Aminopropyl)-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride | HCID 68856073 | — |
| Reactant | 2-(2,5-Dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid [bis-(4-methoxy-phenyl)-methyl]-amide | HCID 86625365 | — |
| Product | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | 65% |
| Product | 2-{5-Chloro-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid [bis-(4-methoxy-phenyl)-methyl]-amide | HCID 86625364 | — |
Reaction Steps
Using the method of Preparation E of 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride, the title compound is prepared from 2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid [bis-(4-methoxy-phenyl)-methyl]-amide and 1-(3-aminopropyl)-4-methylpiperazine as a white solid (65% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-52a82456da654ef2acd80d560e4a4314 |
| Source note | uspto-grants-2009_06 |