Imidazole → (Benzo[b]thiophen-4-yloxy)(tert-butyl)dimethylsilane

HRID 1986244노트

반응식

HRID 1986244 반응식
[OH:1][C:2]1[C:10]2[CH:9]=[CH:8][S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Si:11](Cl)([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12].N1C=CN=C1>ClCCl.CCCCCC>[S:7]1[CH:8]=[CH:9][C:10]2[C:2]([O:1][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12])=[CH:3][CH:4]=[CH:5][C:6]1=2

참가 물질

6

반응물 3

HCID 795ImidazoleHCID 19217Benzo(b)thiophen-4-olHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 68856170(Benzo[b]thiophen-4-yloxy)(tert-butyl)dimethylsilane수율 96.4%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8058Hexane용매

실험 절차

Into a solution of 4-hydroxybenzo[b]thiophene (7.60 g, 50.6 mmol) and tert-butyldimethylsilyl chloride (8.39 g, 55.7 mmol) in dichloromethane (300 mL) is added imidazole (3.79 g, 55.7 mmol) and the mixture is stirred overnight at ambient temperature. The mixture is diluted with hexane (500 mL), filtered and concentrated to a pink oil. The crude material is subjected to chromatography on silica (in hexane) to provide the title compound as a colorless oil (12.9 g, 96% yield).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated to a pink oil

출처 및 근거

ORD 기록
ord-d9046e18fe2e41cfbe630718a6efbda0
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07547691B2

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