1-(3-Aminopropyl)-4-methylpiperazine → [4-(7-Chlorobenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine

HRID 1986250Notes

Reaction equation

HRID 1986250 reaction equation
Cl.Cl.Cl.[S:4]1[C:8]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)[N:10]=2)=[CH:7][C:6]2[CH:26]=[CH:27][CH:28]=[CH:29][C:5]1=2.[Cl:30]C1N=C(C2SC3C(Cl)=CC=CC=3C=2)C=CN=1.NCCCN1CCN(C)CC1>>[Cl:30][C:29]1[C:5]2[S:4][C:8]([C:9]3[CH:14]=[CH:13][N:12]=[C:11]([NH:15][CH2:16][CH2:17][CH2:18][N:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)[N:10]=3)=[CH:7][C:6]=2[CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 866253732-Chloro-4-(7-chlorobenzo[b]thiophen-2-yl)pyrimidine

Product 1

HCID 68856165[4-(7-Chlorobenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine

Procedure

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 2-chloro-4-(7-chlorobenzo[b]thiophen-2-yl)pyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a solid. ES+(m/z) 402 (35Cl) and 404 (37Cl) [M+H].

Workup

  1. customisolated as a solid

Sources & evidence

ORD record
ord-ce6f612b0dfe47c2a9dc329573148417
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

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