7-Chloro-1-benzothiophene → HCID 68856038, compound

HRID 1986251Notes

Reaction equation

HRID 1986251 reaction equation
Cl.Cl.Cl.[Br:4][C:5]1[C:6]([C:22]2[S:26][C:25]3[C:27](OC)=[CH:28][CH:29]=[CH:30][C:24]=3[CH:23]=2)=[N:7][C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[N:9][CH:10]=1.[Cl:33]C1C2SC=CC=2C=CC=1>>[Br:4][C:5]1[C:6]([C:22]2[S:26][C:25]3[C:27]([Cl:33])=[CH:28][CH:29]=[CH:30][C:24]=3[CH:23]=2)=[N:7][C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 110628127-Chloro-1-benzothiopheneHCID 68856938[5-Bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride

Product 1

HCID 68856038HCID 68856038, compound

Procedure

Using the methods of [5-bromo-4-(7-methoxybenzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is synthesized from 7-chloro-benzo[b]thiophene and isolated as a solid. ES+(m/z) 480 (35Cl, 79Br), 482 (37Cl, 79Br or 35Cl, 81Br) and 484 (37Cl, 81Br) [M+H].

Workup

  1. customisolated as a solid

Sources & evidence

ORD record
ord-374666e549ab46c29698c5fa08d6739b
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Reaction notes

Loading…