反应详情

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is synthesized from 2-(2,5-dichloro-pyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(2-amino-ethyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (80% yield). ES+(m/z) 457 (35Cl) and 459 (37Cl) [M(free base)+H].