HuagongsheHuagongshe Chemistry Print Report · For research reference only
Racemic 2-{5-chloro-2-[3-(1-methylpiperidin-3-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide → Racemic 2-{5-Chloro-2-[3-(1-methylpiperidin-3-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Racemic 2-{5-chloro-2-[3-(1-methylpiperidin-3-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide | HCID 68855954 | — |
| Reactant | 2-{5-Chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride | HCID 68856887 | — |
| Product | Racemic 2-{5-Chloro-2-[3-(1-methylpiperidin-3-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride | HCID 68906025 | — |
Reaction Steps
Using the method of 2-{5-chloro-2-[2-(1-methylpiperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride, the title compound is synthesized as the di-hydrochloride salt from racemic 2-{5-chloro-2-[3-(1-methylpiperidin-3-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide. ES+(m/z) 484 (35Cl) and 486 (37Cl) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-7c269d8af3414329b0327aaabc64e0eb |
| Source note | uspto-grants-2009_06 |