HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Methyl-1,4-diazepan-1-yl)propan-1-amine → 2-{5-Bromo-2-[3-(4-methyl-[1,4]diazepan-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Methyl-1,4-diazepan-1-yl)propan-1-amine | HCID 13092853 | — |
| Reactant | 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride | HCID 68856073 | — |
| Reactant | 2-(5-Bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide | HCID 86625343 | — |
| Product | 2-{5-Bromo-2-[3-(4-methyl-[1,4]diazepan-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride | HCID 68856944 | — |
Reaction Steps
Using the method of 2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride, the title compound is synthesized as a yellow solid from 2-(5-bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 3-(4-methyl-[1,4]diazepan-1-yl)-propylamine. ES+(m/z) 543 (79Br) and 545 (81Br) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-5be9fb6e583b450095c3f5baa4ff221f |
| Source note | uspto-grants-2009_06 |