HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate → 2-[5-Bromo-2-(2-piperazin-1-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate | HCID 1514400 | — |
| Reactant | 2-[5-Chloro-2-(2-piperidin-4-yl-ethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride | HCID 68857850 | — |
| Reactant | 2-(5-Bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide | HCID 86625343 | — |
| Product | 2-[5-Bromo-2-(2-piperazin-1-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride | HCID 68906185 | — |
Reaction Steps
Using the synthetic method of 2-[5-chloro-2-(2-piperidin-4-ylethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride, the title compound is synthesized from 2-(5-bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(2-aminoethyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (67% yield). ES+(m/z) 501 (79Br) and 503 (81Br) [M(free base)+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07547691B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-393240e2d0dd4710aa128b703ff15bb7 |
| Source note | uspto-grants-2009_06 |