1-tert-Butyloxycarbonyl-4-(3-aminopropyl)piperazine → 2-[5-Bromo-2-(3-piperazin-1-yl-propylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride

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Reaction Steps

Using the synthetic method of 2-[5-chloro-2-(2-piperidin-4-yl-ethylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide di-hydrochloride, the title compound is synthesized from 2-(5-bromo-2-chloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(3-aminopropyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (59% yield). ES+(m/z) 515 (79Br) and 517 (81Br) [M(free base)+H].

Provenance & Evidence